MP1000 Platform

MetrioPharm is developing a novel class of self-regulating immunomodulators targeting activated macrophages and inflamed tissues.

MetrioPharm's lead compound MP1032 acts at the top of the inflammation cascade, where elevated levels of reactive oxygen species (ROS) trigger cellular oxidative stress and thereby a variety of disease processes.

MP1032 is a novel small molecule ROS scavenger. As a first-in-class immunomodulator, MP1032 does not suppress the immune system. The molecule targets cellular oxidative stress and thereby reduces inflammatory markers such as TNF-alpha, IL-6, IL-12, while ROS are maintained at physiological levels essential for normal cellular function.

 

 

MetrioPharm MP1000 Platform Immune Modulation