Mechanism of Action
The First-in-Class Self-Regulated Macrophage Metabolic Modulator 

MetrioPharm's lead compound, MP1032, modulates the redox balance of reprogrammed, pathogenic macrophages. In these activated macrophages, MP1032 downregulates pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, which are downstream of NF-κB, back to physiologic levels only.

In addition to its anti-inflammatory effects, MP1032 has demonstrated host-directed antiviral and antibacterial activity in several preclinical models and has also shown antithrombotic effects.

MP1032’s self-regulating mechanism is based on redox biology:

• MP1032 is a first-in-class, self-regulating small molecule that is activated only in the presence of elevated reactive oxygen species (ROS) in reprogrammed, pathogenic macrophages. It helps restore redox balance and inhibits the activity of poly(ADP-ribose) polymerase 1 (PARP-1).
• Unlike conventional antioxidants, MP1032 selectively scavenges ROS back to physiologic levels but not below. It remains inactive at physiologic ROS levels (no overshoot), thereby preserving ROS-dependent signaling pathways that are essential for normal cellular functions.

For more information on MP1032 and MetrioPharms development pipeline, please download our corporate slide-deck: